Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy
نویسندگان
چکیده
منابع مشابه
Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism.
OBJECTIVE To compare phenotypes of 2 age-related macular degeneration (AMD) susceptibility genes: LOC387715 and complement factor H (CFH). METHODS Phenotypes of 755 AMD cases were characterized. The number of LOC387715 (T allele at rs10490924, or A69S) and CFH (T1277C at rs1061170, or Y402H) risk alleles were determined in each case. Individuals were divided into 5 groups by genotype: group 1...
متن کاملAssociation of complement factor H polymorphisms with exudative age-related macular degeneration.
PURPOSE Variants in the complement factor H (CFH) gene have been reported to be associated with age-related macular degeneration (AMD). We conducted a case-control association study to investigate the association of 6 single nucleotide polymorphisms (SNPs) in CFH with exudative AMD in the Chinese population. METHODS We recruited 163 cases and 244 controls, all ethnic Chinese, with complete op...
متن کاملAssociation of CFH, LOC387715, and HTRA1 Polymorphisms With Exudative Age-Related Macular Degeneration in Mainland Chinese
Purpose: To examine the common single-nucleotide polymorphisms in complement factor H (CFH), LOC387715, and HTRA1 genes as potential risk factors for exudative age-related macular degeneration (AMD) in the mainland Chinese. Methods: A cohort of 121 unrelated patients with exudative AMD and 132 ageand sexmatched control subjects, all unrelated ethnic Chinese from Northern China, enrolled in this...
متن کاملComplement Factor H Y402H and LOC387715 A69S Polymorphisms in Association with Age-Related Macular Degeneration in Iran
PURPOSE To determine the frequency of complement factor H (Y402H) and age related macular degeneration susceptibility gene 2 (A69S) single nucleotide polymorphisms in patients with age-related macular degeneration (AMD) and in matched non-AMD controls in an Iranian population. METHODS Seventy patients with AMD and 86 age- and sex-matched controls were recruited and examined. Peripheral blood ...
متن کاملComplement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.
The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD). However, the precise mechanism by which this CFH variant impacts the risk of AMD remains largely unknown. Oxidative stress plays an important role in many aging diseases, including ca...
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ژورنال
عنوان ژورنال: Eye
سال: 2008
ISSN: 0950-222X,1476-5454
DOI: 10.1038/eye.2008.28